What is dipicolinic acid?

Dipicolinic acid is a chemical compound with the molecular formula C7H5NO4. It is a derivative of pyridine and is sometimes also referred to as pyridine-2,6-dicarboxylic acid.

One of the unique properties of dipicolinic acid is its ability to chelate with metal ions, particularly calcium ions. This property is utilized by certain bacteria, such as Bacillus species, as a way to protect their DNA from damage during periods of environmental stress, such as dehydration or high temperatures.

Dipicolinic acid is also commonly found in the spores of certain bacteria, where it plays a crucial role in the heat resistance of these spores. When spores are heated, dipicolinic acid binds to calcium ions to stabilize the DNA and help protect it from damage.

Overall, dipicolinic acid is an important molecule in the biology of certain bacteria, as well as a potential target for the development of antimicrobial agents.